ABSTRACT
<p><b>OBJECTIVE</b>To compare the therapeutic effects of minocycline, metronidazole and iodine glycerin on periodontitis.</p><p><b>METHODS</b>A total of 123 patients were randomly divided into 3 groups to receive the 3 topical remedies administered into the periodontal pockets. The total response rate of the 3 treatments was calculated, and the changes in GI, PL I, PD and BO P were observed.</p><p><b>RESULTS</b>All the clinical indices of the 3 groups showed obvious improvements after the treatments compared with the baseline levels. The clinical indices of minocycline group and metronidazole group showed significant greater improvements than those of iodine glycerin group. The total response rate in minocycline group and metronidazole group was higher than that of iodine glycerin group.</p><p><b>CONCLUSIONS</b>Minocycline and metronidazole as topical remedies can be effective auxiliary treatments of periodontitis.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Administration, Topical , Anti-Bacterial Agents , Therapeutic Uses , Iodine , Therapeutic Uses , Metronidazole , Therapeutic Uses , Minocycline , Therapeutic Uses , Periodontal Pocket , Periodontitis , Drug TherapyABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of liquorice in functional modulation of intestinal P-glycoprotein (P-gp) in rats.</p><p><b>METHODS</b>An in vitro diffusion chamber system (Ussing chamber) was used to examine the direct effect of liquorice decoction on rhodamine 123 (a subtrate of P-gp) transport and evaluate the permeability of rhodamine 123 or fluorescein sodium through rat jejunum membranes after oral administration of liquorice decoction.</p><p><b>RESULTS</b>Direct application of liquorice decoction did not obviously affect rhodamine 123 transport across the intestinal mucosa. Oral administration of liquorice decoction (10 g/kg, twice daily for a week) significantly increased the absorption of rhodamine 123 and also enhanced rhodamine 123 secretion across the jejunum mucosa. Liquorice had no obvious effect on the transport of CF across the jejunum mucosa.</p><p><b>CONCLUSION</b>Liquorice may slightly inhibit P-gp function in the intestinal mucosa to increase the intestinal absorption of rhodamine 123.</p>